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One difficulty lies in the six-party complexities.
One difficulty lies in Habermas's assumption that in public discourse over controversial political issues, citizens can separate the moral constraints on acceptable solutions, presumably open to general consensus, from ethical-political and pragmatic considerations, over which reasonable citizens may reasonably disagree.
One difficulty lies in the interpretation of a list of differentially expressed genes, or in how to plan new experiments given that knowledge.
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One fundamental difficulty lies in the vagueness of the terminological construct of "social competence".
One major difficulty lies in recognising an object despite profound differences in the retinal images it projects, due to changes in view, scale, position and other identity-preserving transformations.
One difficulty of homotopy methods lies in the choice of a sufficiently regular deformation that allows the convergence of the homotopy method.
Anything that blocks awareness of the dividing line between knowing and not knowing can be an obstacle to learning, and herein lies one difficulty with expertise mission creep.
One difficulty in interpreting overexpression lies with the fact that a comprehensive database of RNA expression from RNA sequencing of normal human tissues does not presently exist, although there are efforts to produce such a database (for example, GTEx [ 10]).
One difficulty associated with this methodology lay in defining the conditions with which to compare the HWF treatment, as ordinary cell culture conditions do not necessarily mirror ordinary physiological growth conditions for tumor cells.
The difficulty lies in knowing when to abandon one goal and move on to something else.
One difficulty in projects that articulate fashion and technology trends lies in the balance between these two potentially antagonistic poles.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com