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"One cannot design by committee.
They need to recognize that the doctor-patient relationship is important to both the doctor and the patient and that one cannot design a protocol in such a way that ignores the feelings of the doctor and patient about how important it is to provide good care".
Industries appear to have their own specific carbon footprint profiles, and one cannot design generic relevance tests that tell which data to collect.
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One cannot overemphasize the material design and testing that go into these seemingly mundane applications.
Given that this is a cross-sectional study design, one cannot rule out the possibility of reverse causation where the stress of being subject to food insecurity causes people to smoke.
However, one cannot limit the bonding joint design to longitudinal shearing, although that remains important.
When chemical structures are constructed during the de novo design process, one cannot take for granted that the chemical synthesis of such compounds is feasible at all.
Regarding study design, as one cannot randomize patients to BMI categories, only observational studies of BMI and mortality are possible, so we have to adjust for confounding through other means, such as regression.
One cannot forget the concentration camps designed to kill off entire populations from Namibia to Libya, nor the distribution in North America of "smallpox blankets", presented to Native Americans as gifts, and intended to wipe out everyone who touched them.
The question, of course, is a rhetorical one; even the most brilliant economist cannot design an economic system that can function without water, trees and pollinators, not to mention metals and fossil fuels.
This practice is fundamental in art and design education; however, one cannot assume that it is part of the normal training of other disciplines, such as computer science, that makes up the interaction design team.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com