For some we cleaved open the earth, and some were drowned".
Because caspase-activated deoxyribonuclease (CAD) is an endonuclease that is activated once caspases cleave its inhibitor (ICAD) and because TNFRSF1B depletion results in DNA fragmentation in endothelial cells, we overexpressed zebrafish ICAD in TNFRSF1B-deficient embryos.
Once activated, they cleave and activate the executioner caspases [11].
Once activated, caspases cleave a host of cellular substrates, leading to morphological hallmarks of apoptosis, including DNA fragmentation.
Caspase protease activity is essential for apoptosis; once active, caspases cleave hundreds of different proteins leading to rapid cell death with distinctive biochemical and morphological hallmarks (Taylor et al, 2008).
Neither Gold nor McGregor can quite excavate the tragedy in Stoppard's essentially realistic view of love as something that we at once cleave to and reject, especially when we want it most.
We still cleave to the notion that because we need food to survive, hyper-expensive restaurant experiences are somehow amoral.
To test the diffusion distance of the protease-digested goods, we added a LasB substrate to the plate that fluoresces once cleaved by LasB and then repeated the competition experiment above with 1 cm colony spacing.
The Black Keys don't sound remotely stripped-down any more, but they too once cleaved to this ascetic no-bass sound.
Once cleaved at aa495, the single chain proHGF (inert form) reverts to the active two-chain form of HGF, and mediates a wide range of signaling pathways by binding to the c-Met receptor (Nishida and Hirano, 2003).
