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Conversely, in the case of the unsaturated analogues, their tight binding to the enzyme as well as a high tolerance against the side chain of residue 2 suggest that they bind to the transition state conformation of the enzyme, once more emphasising the importance of geometry for catalysis.
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people centred service delivery, meanwhile, as highlighted by Ferrer et al., for instance, once more emphasises the importance of the values and principles of PHC, notably first contact care when needed, person-focused care over time (longitudinality), and comprehensiveness and co-ordination of services (Starfield 2009).
36 In the light of primary prevention of cardiovascular disease this finding once more emphasises the need to also focus on risk factors other than hyperlipidaemia, as lipid lowering treatment has so far not been proved beneficial to reduce the risk of non-ischaemic heart failure.
Clearly, these results once more emphasise how volume expansion is deleterious in fluid non-responders.
It should be once more emphasised that the present book was conceived from an idea where the most important aspects of numerical modelling are introduced, as computer simulations of practical cases of numerical experiments are presented.
This phenomenon is more emphasised on an island because people have historically lived more isolated.
A relevant point of attention is, however, that both centres represent highly specialised, reference centres for ovarian cancer surgery, emphasising once more the tight association of surgical excellence and low operative morbidity (Aletti et al, 2009).
We hope that the findings from the OPEN project will contribute to these decisions and implementation processes, emphasising once more the needs of academia and the public for unrestricted access to an unbiased body of evidence of complete results of all clinical trials.
Arsene Wenger's need to strengthen his Arsenal squad further was emphasised once more as injuries overshadowed progression to the Champions League group stages for a 16th successive season.
Dujarric added: "We would like to emphasise once more than no conduct of this nature can be tolerated and that every allegation will be taken seriously".
It is important to emphasise, once more, that it is precisely because we live in and on the landscape, that it is crucial we look after it and put it first and foremost in our priorities.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com