In other words, cancer, once manifest, becomes an inherited disease of the cell and is therefore self-perpetuating.
Each has its season, its fate, its place in a cosmos whose ordering principles are at once manifest and manifestly unknowable.
Thus, the early postnatal (and prenatal) environment appears to program subsequent obesity and provides a potential therapeutic target, which will hopefully translate into improved intervention strategies to affect the epidemic of obesity, a condition which, once manifest, has proven particularly hard to treat.
Furthermore, both cell types exhibited some hypertonic damage that was not apparent while the cells were in hypertonic solution and only manifested once the cells were brought back to isotonic conditions.
This is based on our data showing that BBB dysfunction only manifested once vascular tau emerged at 9 months, well after neuronal loss and total tau accumulation begin at 2.5 months and gliosis at 4 months [ 24, 43].
Her passion for the sport of kings is well known and once accidentally manifested itself when, in announcing details of a bill at the state opening of parliament 10 years ago, she referred to the National Hunt Service, before quickly correcting it to National Health Service.
Lilla's book at once acutely manifests these difficulties and tries to resolve them.
Based on the isotherms, the pore size distribution and specific surface area are deduced according to the Barrett Joyner–Halenda model, and the corresponding plots are presented in Fig. 6b, which once again manifest the existence of well-developed porosity with an average pore size centered around 20 nm and a wide distribution from micropores to macropores in both samples [2, 26].
