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One such design, the participant preference trial, provides additional information in an ecologically valid manner, once intervention efficacy has been demonstrated.
Once intervention delivery began, there were few major challenges.
Information on the study variables will be collected on three occasions: when the woman enters to the study (baseline), once intervention is complete (at three months) and after three more months of follow-up (six months).
In contrast, once intervention efficacy has been established in one particular case, it may no longer be necessary to invest in costly efficacy evaluation; rather it may suffice to evaluate the effect of the intervention on health systems, such as changes in coverage with ART.
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Once interventions are paid for, the incentive for research disappears.
Once "Interventions" began, the novelty of Carter's longevity receded, and the music became the most interesting thing.
Too frequently, however, studies report that the effects of interventions targeting those factors are not maintained once interventions are withdrawn.
Such responses, which Pop-Eleches and Urquiola refer to as "equilibrium effects", may only emerge once interventions are taken to scale and sustained for a period of time.16 For example, if tracking is sustained, more experienced teachers may sort toward the higher achievement classes, and their ability to do so may gradually become enshrined in norms or even union contracts.
Given the many uncertainties in malaria transmission dynamics and limitations in its monitoring, it will be difficult to assess which if any of the scenarios outlined above may occur once interventions are introduced.
Allocation concealment—Intervention status was disclosed once interventions began in both countries.
These choices reflect a demand for care that is necessary once interventions are made available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com