Once accumulating in the tumor tissues, DATAT-NP is reactivated by tumor acidity to promote cellular uptake, resulting in enlarged fluorescence/MR imaging signal intensity and elevated in vivo PDT therapeutic effect.
Acquisition of KOH-soluble fluoride was detectable in the central, fluoridated samples of both groups, Mirafluorid and Duraphat, with the latter once accumulating statistically significantly more KOH-soluble fluoride (P = 0.00015).
At Syracuse, where he received a degree in theater, he once accumulated $237 in parking tickets.
In addition, once accumulated, Cu was efficiently retained (i.e., elimination rate constants were generally not significantly different from zero).
Once accumulated, the money is deployed wherever the men and women running them feel there is an opportunity to profit.
A few are adjusting to their straitened circumstances, shedding staff and assets as quickly as their star traders once accumulated fast cars and sharp suits.
Once accumulated at the targeting site, the CPP modified drug is released from the blockage by a second triggering agent, while remaining inactive in the circulation during tumor targeting thus aborting its effect on normal tissues.
As Oxfam say in the report: "Once accumulated, the wealth of the world's billionaires takes on a momentum of its own, growing much faster than the broader economy in many cases".
Once accumulated in the body, Cd2+ is stored mainly in the bone, liver, and kidneys causing renal damage, pulmonary insufficiency and negative effects on blood.
Once accumulated at the tumor site, the polymer-lipid hybrid NPs as a whole would easily into the interior of the tumor cells to exert the pharmacological effects.
An interesting observation we made in this study is that once accumulated in the Golgi apparatus, intracellular Zn pools are then redistributed into smaller vesicles dispersed throughout the cell in response to subsequent prolactin stimulation in vivo.
