Finally, it was not possible to directly evaluate the impact of comorbidities on the total burden because questions on coexisting diseases had not been included in the screening questionnaire, in order to minimize its length and therefore increase the response rate [ 18].
The additional consideration of indirect costs and QoL aspects allows an even more detailed and comprehensive view on the total burden from the families' perspective.
Some data suggest that MRSA infections replace MSSA infections with no effects on the total burden of Staphylococcus aureus infections (a scenario further referred to as "replacement") [16], [17].
Data on hospital incidence, recurrence and event risk ratios across the vasculature will also permit modelling the effect of shared secondary preventive treatments, such as cardioprotective pharmacotherapy and lifestyle changes, on the total burden of hospitalised atherothrombosis.
The Wei, Lin and Weissfeld method allowed analysis of multiple cardiovascular disease events, which better reflects the impact of the intervention on the total burden of cardiovascular disease among screen-detected patients.
Risk assessment methods have now been developed for this purpose (Künzli et al. 2008), and we have shown the substantial impact this has on the total burden of disease attributed to pollution (Perez et al. 2009).
Quantifying time loss and the associated potential productivity losses thus allows for policy discussions to focus on the total burden of illness among different diseases and not merely the clinical aspects of any given disease [ 3].
When describing characteristics of the study population, comparing functions and EQ-5D, the cohort was divided in three different groups, based on the total burden of net days SLDP the year before MMR; no SLDP, part-time SLDP (< 360 days) and full-time SLDP (≥360 days).
Their projections indicated that the aging of the population and the increase in cardiovascular survival would partially mitigate the effect of the declining incidence on the total burden of stroke, leading to a further increase in major stroke prevalence among the oldest age groups.
The benefit and cost-effectiveness of HPV immunization will depend on the total burden of HPV-related cancer, the proportion of ESRD patients with active HPV infection at the time of vaccination, and the immunogenicity of the vaccines among these patients.
