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As expected, the positive drug pairs seemed to be helpful for predicting new targets (e.g. α1 of Motilium, α2 of Xenazine and δ of prantal) by annotation transfer based on the shared target.
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Another possibility is that 5HT and DA have opposite actions on certain of the shared targets, and changing the function of both amines simultaneously yields a phenotype different from the one obtained by manipulating each of the amines alone.
Strategists in both camps managed at one point to find common ground as they pounced on a shared target: the media.
Together, these observations show that MUL1 acts in parallel to the PINK1/parkin pathway on a shared target mitofusin to maintain mitochondrial integrity.
We defined a signature for the ubiquitous tissue factor, E2F4, based on its shared target genes in multiple tissues.
It is essential that the resolution of the BRM/SYD and MP binding sites on shared target promoters is refined by additional ChIP-PCR (or ChIP-seq) mapping along the chromatin in these regions.
Both pathways converge on a shared target mitofusin to maintain mitochondrial integrity in both Drosophila and mammals.
We found that this Naive Bayes assumption was valid for the vast majority of co-regulators, indicating that most co-regulators act independently on their shared target.
( C_{s}^{n} ) is a drug drug similarity matrix based on the number of shared targets between drugs; ( T_{s}^{n} ) is a target target similarity matrix based on the shared drugs.
This brings into focus the choice between therapies targeting specific genetic mutations and those operating on shared targets, as well as the need to combine multiple therapies to treat diverse subclones.
In summary, these analyses reveal that the relatively large effect of Cdx4 is not solely a quantitative effect on shared targets, and that qualitatively different effects are caused by disruption of each of the three Cdx genes in development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com