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The enantioselectivity was strongly dependent on the linker structure.
Sterical improvements on the linker chemistry were developed for high-affinity binding.
The increase in hepatic accumulation depended largely on the linker chemistry of each cholesterol-conjugated ASO.
From the results of Figure 3A, the signal intensity of each strain depended on the linker length.
In ADC chemical conjugation, accessible amino acid residues on the surface of the antibody undergo a controlled reaction with a reaction handle installed on the linker.
CLH-3b activity is reduced by phosphorylation or deletion of a 14-amino-acid activation domain (AD) located on the linker connecting CBS1 and CBS2.
Similar(27)
The influence of the chemical nature of the linker on properties of studied compounds was observed and analyzed.
The effective concentration p depends on the length of the linker and the distance between the linker attachment points in the bound state.
Linker-dependent false-negative binding has been attributed to the influence of the linker on the presentation of the glycan relative to the support surface.
The degree to which linker chemistry affects glycan presentation depends both on the length of the linker (shorter being more likely to restrict access to the glycan), and on the orientation of the linker relative to the array surface.
These have focused in particular on the role of the linker region between the voltage sensor and PTEN domains.
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