Sentence examples for on the apc from inspiring English sources

The limited effects on pulmonary haemodynamics may be explained by a lower systemic concentration of the active drug, which could be caused by limited absorption of APC from the airways or even a damaging effect of the nebuliser on the APC molecules.

They were generated in HLA-DR transgenic mice, but respond to human APC as previously described [9], and secrete IL-2 in proportion to the amount of specific peptide-MHC on the APC surface.

Moreover, the efficiency of self-antigen presentation depends on the ability of thymic APCs to process and present self-antigen, and the density of MHC and co-stimulatory molecules on the APC surface.

While working on the APC project, Dr. O'Rourke was surprised to learn that researchers in the colon cancer field were using an outdated and inadequate mouse model a realization that led him to his second preclinical project.

It is long-recognised that bacteria (and indeed other pathogens) belonging to genetically distinct phyla are capable of modulating the repertoire of co-stimulatory and co-inhibitory molecules expressed on the APC surface23, thus affirming the critical importance of said receptors in the directing of adaptive immune responses.

At least two signals are required for T-cell activation: Signal 1 results from recognition of MHC/peptide complexes on the APC by cell surface T-cell receptors (TCR), whereas Signal 2 is induced by the interactions of co-stimulatory molecules on APC with their complementary receptors on T cells.

30 However, it is more likely that the different effects of Notch inhibition on the Apc-mediated phenotype are linked to different β-catenin activation thresholds.

The cancer cell lysate used in these studies as the antigenic source contains 'danger' signals, such as HMGB1 and Calreticulin, which are capable to interact TLR4 and rage on the APC-promoting DC immunogenicity (Tittarelli et al, 2012).

During the later stages of mitosis, Cdh1 replaces Cdc20 on the APC/C to form the APC/C-Cdh1 APC/C-Cdh13], [25], [26], [33].

We argue that shedding more light on the APC/C is also important to understand cancer and could help the design of treatment.

Based on the APC and GCAPC, Figs. 2, 3, and 4 depict the estimations of range-Doppler plane X utilizing AMPC, FAMPC, and MAMPC, respectively.