Sentence examples for on target efficacy from inspiring English sources

Plasma and tumors were harvested after 1, 2, 4, 8, 12, and 24 h and analyzed for drug concentrations and effects on target efficacy biomarkers.

Moreover, each technology exhibits its own set of off-target effects and limitations in on-target efficacy.

Cho H, Du X, Rizzi JP, Liberzon E, Chakraborty AA, Gao W, et al. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.

In silico single guide RNA (sgRNA) design is a key step for successful gene editing using the CRISPR system, and continuing efforts are aimed at refining in silico sgRNA design with high on-target efficacy and reduced off-target effects.

Thus, FRAP assays offer a potentially universal method for generating cell-based assays for bromodomain-containing proteins that allow compounds to be tested for cell permeability and on-target efficacy.

Together, these results demonstrate that FRAP assays offer a potentially pan-bromodomain method for generating cell-based assays, allowing the testing of compounds with respect to cell permeability, on-target efficacy and selectivity.

The target efficacy was 95%.

Here we report on the evaluation of clot-targeting efficacy, lipase-triggered drug release and resultant thrombolytic capability of the PMINs in vitro, and subsequently demonstrate that intravenous delivery of thrombolytic-loaded PMINs can render targeted fibrinolysis without affecting systemic hemostasis, in vivo, in a carotid artery thrombosis model in mice.

The tested analogues were selected on the basis of their good PC targeting efficacy, as previously reported.

Since xenograft tumor models have not been established in minipigs and Cynomolgus monkeys, safety testing of tumor targeting drug candidates can only address tissue-cross-reactivity (TCR) and adverse on-target effects but not efficacy.

When modified on the surface of nanocarriers, those peptide ligands would readily degrade and the targeting efficacy is significantly attenuated.