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Recent findings from the Phase III study "ALLEGRO" indicate that LAQ has even more pronounced effects on sustained disability progression as well as on brain atrophy compared to its effect on relapses [ 7, 13].
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It has been demonstrated that relapses produce a measurable and sustained effect on disability progression in patients with relapsing-remitting multiple sclerosis (Lublin et al., 2003), but others did not find a consistent effect of on-study relapses on the subsequent development of sustained disability increase, during a typical clinical study observation period (Young et al., 2006).
This effect was more pronounced for 12-month sustained disability worsening events.
CARE-MS II also demonstrated improvement in sustained disability progression versus IFNβ-1a [ 92], although a disability benefit according to the Expanded Disability Status Scale compared with IFNβ-1a was not seen in the CARE-MS I trial [ 91].
Politically it was on sustained red alert.
Her voice can wobble on sustained tones.
Technology, however, depends on sustained public trust.
In 61 of the cancer survivors, no labour capacities (full and sustained work disability) were present.
More recent findings [ 21] suggest that even a consistent effect of on-study relapses on subsequent "sustained progression" could not be interpreted as evidence for a link between relapse frequency and the accumulation of true, unremitting disability.
And there's something deeply tragic about a love that cannot sustain such disability.
Of people who survive a ruptured brain aneurysm, about two-thirds will sustain permanent disability.
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