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Most of the latter recognize classical or non classical major histocompatibility complex (MHC) class I molecules on surrounding cells.
Thus, as resting NK cells from TAP-deficient patients express such receptors but have no cytotoxic activity, one might postulate another "licensing mechanism" that would be deficient in these patients, or alternatively that HLA class I levels on surrounding cells would simply be too low to correctly educate NK cells.
DAMPs are released from necrotic cells and bind to extracellular receptors on surrounding cells.
However, the effect of their addition on surrounding cells and tissues has not yet been investigated.
Factors released from an ulcer region, or, more generally, from an abnormal urothelium, may have paracrine influences on surrounding cells.
Although long-term protein production may enhance cartilage repair, there are also concerns about the formation of potential oncogenic effects on surrounding cells.
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In summary, here we uncover an intimate relationship between morphogenetic events and cell packing within a tissue that is dependent on surrounding cell density.
Proof-of-principle experiments exploring cell competition and compensatory proliferation in D. melanogaster larval development suggest a dual role for apoptosis during early tumorigenesis with the need to dampen intrinsic pro-apoptotic signals to promote tumor cell survival on one hand, and the benefit from the death of surrounding cells on the other hand.
During embryonic neural development, axon tips ("growth cones") are guided through a dynamic three-dimensional (3-D) landscape by soluble chemotropic factors and by immobilized, growth-permissive or growth-inhibiting contact cues present in the extracellular matrix and on the surface of surrounding cells.
Such a community effect means that the behavior of a cell in our model simulation deeply depends on the context of surrounding cells.
To test whether the translocation system in the VZ is cell autonomous or dependent on the activity of surrounding cells, we observed the behaviour of fluorescent microbeads in cultures of brain slices.
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