The increase in dimensionality of such context-dependent models warrants model reduction strategies [ 15] based on merging similar evolutionary contexts.
Future research should concentrate on studying such context-dependent genetic benefits and employ experimental manipulations and quantitative genetic techniques to give conclusive evidence.
Based on our experience, such context-specific effects in a few variants are unavoidable when a large number of synonymous variants of a gene are systematically interrogated.
The method is motivated by (i) large differences between such contexts on the web, (ii) the facilitation of goal oriented search using context classifiers, and (iii) attractive fast adaptation properties, that could counteract diversity of web environments.
Our observation that synonymous codon replacements at multiple locations along sinR have a stereotypical effect on biofilm formation argues against such context-specific mechanisms (except for the three exceptional cases noted above).
Similarly, in a wide ranging guide on strengthening CHW programmes at scale, Perry & Crigler [ 14] assert the need for embedding CHW programmes within national and sub-national system contexts, and for planning based on situation appraisals that assess such contexts.
The extent to which 'best practice' can be shared and translated across such contexts will depend on a wide range of factors particular to the nature of the research and its location(s).
Our concern in such contexts is always normative rather than explanatory but the reasons we decide to act on in such contexts may subsequently be cited in explanation of what we do, at least in cases where we succeed in conforming our actions to the decisions in which our deliberation issues.
