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To explore the cause of developmental arrest by PARylation inhibition, we first focused on spindle formation, because Parp1 signals were predominantly localized to the meiotic spindles and cytoplasmic asters of MII oocytes (Figures 1A, B & 3).
Occasionally on spindle, dogwood and snowberry.
People can also vote for their favorite city by registering with their zipcode on Spindle.
However, this doesn't mean that you can rush to add all of your friends on Spindle.
Numerical simulations on spindle motors with hydrodynamic bearings indicate that base flexibility could lead to significant spindle vibration.
The tumor in this case had for a large portion of sarcomatous components that was based on spindle shape cell proliferation and cytokeratin.
This provides a cellular mechanism for high local concentrations of p60, like those found on spindle poles, to maintain severing activity while most of the protein is inhibited.
Next we analysed the effect of KEN box mutations on spindle checkpoint function(s) of Mad3p.
On spindle MTs, majority of dynein is transported by +TIPs on the growing MTs.
This shows that Eg5 does not saturate the available binding sites on spindle microtubules at the critical concentration.
We decided to quantify the amount of wild-type and mutated Eg5 on spindle microtubules in Xenopus egg extract.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com