The largely off-screen deliberations – conducted last week ahead of the broadcast of the on-screen trial, which concludes with the verdict next Friday – will determine the show's storyline.
Effect estimates are based on results from screening trials in Utrecht (DOM-project) and Nijmegen, and on bi-annual screening of women aged 50-70.
Note that in this task, the target bar stayed on-screen throughout the trial.
We have estimated an overall PSA test sensitivity of 80%, which is comparable to Hakama et al (2007) estimate of 85% using the incidence method and based on randomised prostate cancer screening trial in Finland.
There were always two stimuli on screen on every trial (WM load 2).
After a 500-ms fixation cross interval (this cross remained on screen throughout the trial with instructions to maintain fixation), two differently colored and angled semicircles were presented for 500 ms in the center of the computer screen ("sample display").
6 Results from the on-going Dutch-Belgian lung cancer screening trial (NELSON), investigating whether LDCT screening reduces mortality compared with no screening at 10 years follow-up, are yet to be published.
For paired screening tests with bivariate normally distributed scores, we give formulae and programs to quantify the effect of paired screening trial bias on a paired comparison of area under the curves.
This study, based on the Finnish prostate cancer screening trial data, suggests that the proportion of screen-detected cancers that are likely to be overdiagnosed is inversely related to polygenic risk, that is, proportion overdiagnosed decreases with increase in polygenic risk.
The Dutch MRI study is the only other high-risk MRI screening trial to report on long-term outcomes in their screened women (Rijnsburger et al, 2010).
Based on the results from Gothenburg Breast Screening Trial we calculated ICR = 0.21 and PICR = 0.20.
