Two studies provided data on remission, but only one of these showed a significant difference between citalopram and placebo (RR=1.59, 95% CI 1.10 to 2.31).
Of these, one showed a significant improvement on remission rate in collaborative care group at the end of the 24 month's treatment (adjusted RR = 1.53, 95% CI =1.11-2.12) [ 32].
The presence of the disease model and at least one indigenous model had a stronger impact on remission than the disease explanation per se.
Gradual reduction of anakinra dosing after a median of 12 months on remission seemed to be safe in our series, because only one of seven patients under alternate day treatment relapsed.
"The importance of this was that it focused on remission, not response, on treatments to help people get well, not just better," said Dr. Thomas R. Insel, director of the National Institute of Mental Health, which financed the study.
The only AIA symptom without a notable effect on remission was irritability.
Heightened amygdala reactivity to emotional stimuli is characteristic of depression; it can predict treatment efficacy and reverses on remission.
The presence of severe AIA at baseline also had a statistically significant negative effect on remission, when defined as a YMRS Total score of <12.
In contrast, the presence of depressive symptoms defined by a MADRS Total score of ≥20 had no notable effect on remission rate.
In this special section of the Journal, separate articles extend these findings to the impact of TADS treatments on remission, speed of response, function and quality of life, predictors of outcome, and safety during the first 12 weeks of treatment.
In an exploratory step, we also tested for a DTI measure – age interaction and a DTI measure – baseline MADRS interaction effect on remission.
