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"The team have got a few bits to work on, our structure wasn't quite there," the back-rower told BBC Radio Jersey.
More details on our structure will be given later.
We also find that an ILY-derived peptide based on our structure disrupts the interface and competes for pore formation.
DOI: http://dx.doi.org/10.7554/eLife.01085.026 To determine the effect of the missing wedge on our structure we performed tomography-simulations using an idealized railroad-like structure model.
The high conservation enables us to homology model both Ups1 and PRELID1 on our structure to examine whether the SLMO proteins are likely to promote phospholipid transfer between membranes (Fig EV 2).
To begin to understand the mechanisms involved in modulating sGC activity, we mapped sGC residues that have been shown to significantly impact activity and activation on our structure of the inactive heterodimer and our model for the active heterodimer.
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"Typically, we're doing rehabilitation work on our structures.
Based on our structures, we engineered a mutant that deacetylates peptides by using nicotinic acid adenine dinucleotide (NAAD) as a cosubstrate and is inhibited by nicotinic acid.
Starting from microtomography images of the trabecular bone, we prepared several Osteoprints through two-photon polymerization and tested the behavior of SaOS-2 bone-like cells cultured on our structures.
In this study, we used transgenic mouse technology to expand on our structure-function approach to elucidating the role of the cytoplasmic tail of Cldn6 in epidermal development and the formation and maintenance of skin barrier integrity.
Based on our structures, we additionally designed a R81A/Y87F double mutant that we expected to have the strongest effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com