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No negative side effects on organ function were seen.
Travel time needs to be as short as possible; every hour between harvest and transplant can have deleterious effects on organ function.
Thus, the effects of this procedure on organ function and survival do not appear to be due solely to immediate changes in the usual measured circulating cytokines.
At relatively low doses there is little to no effect on organ function or tissue architecture, but at higher doses, acute inflammation and tissue damage can occur that is sometimes quite profound.
It is also of concern that associated tissue damage might occur, such as the formation of excess fibrous connective tissue (fibrosis), or whether adhesions to surrounding tissue might arise that could limit implant function and have adverse effects on organ function.
Figure 3 Critical IAH threshold calling for surgical decompression dependent on organ function and dysfunction.
Failure to normalise the microcirculation following resuscitation has significant effects on organ function [18].
Studies concerning fluid and volume therapy prove an adverse effect of tissue edema formation on organ function and mortality.
It also reviews the potential toxic effects of lithium on organ function since managing these risks is also essential in long-term lithium therapy.
The deleterious effects of accidental hypothermia in multiple trauma patients contrast the beneficial effect of induced hypothermia on organ function during ischemia in elective surgery [9].
In other words, changes in immunophenotype associated with progression of sepsis to severe sepsis/septic shock may merely reflect the consequences of clinical interventions and/or indirect effects on organ function that partly reflect pre-existing comorbidities.
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