On the other hand, the fact that psychostimulants act on numerous pathways hampers the investigation of the neurobiology underlying the observed behavioral changes.
Presumably, adipose tissue and its products may have some impact on numerous pathways of response to trauma, sepsis and stress.
Our data contributes to the accumulating evidence showing that adipose tissue is an active organ secreting multiple adipocytokines, which may have an impact on numerous pathways of response to critical illness.
On the other hand, numerous pathways and molecules have been implicated in vascular hyporesponsiveness induced by sepsis.
Although WNTs were originally classified as signaling through canonical (via β-catenin) or non-canonical pathways, recent studies indicate that many WNTs activate numerous pathways, depending on the expression profile of WNT receptors (including Frizzled family members), LRP5, LRP6, ROR1, ROR2 and RYK10,11,12.
While detailed studies on cilia-related pathways have revealed numerous pathways regulated by or in the cilium, the interplay of different pathways remains very poorly understood and requires further studies.
Pi plays a central role in numerous aspects of plant metabolism, and Pi deficiency has profound effects on numerous metabolic pathways as well as on gene expression [ 38, 39, 44, 51].
This binding is shown to have a variety of effects on numerous signalling pathways, all of which demonstrate some sort of intervention in the progression of OA [ 13, 21, 32, 36, 38, 42, 43, 46, 59, 61, 104, 116].
Building on a system wide analysis of Neurospora's response to growth on cellulosic biomass (Tian and Beeson et al., PNAS, 2009), we have discovered numerous pathways used by fungi to consume the plant cell wall.
WASH is a critical component to ensuring adequate nutrition and can affect people through numerous pathways.
These reports indicate that propionate can contribute to energy homoeostasis through effects on numerous cellular metabolic pathways and receptor-mediated mechanisms and provide a potential explanation for the differences in body weight gain and adiposity observed between supplementation groups in the long-term study.
