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Sox9 repression seems to rely on multiple pathways in addition to the one described here, as FOXL2 and ESR1 have been described to co-bind a SOX9 regulatory element in the ovary.
Drugs that act on multiple pathways are being developed, and targets that are expressed across all phases of the disease are selected.
In this study Fisher and colleagues suggested that the protective effects of ascorbic acid are due to its pleotropic actions on multiple pathways and it is possible in the current study, a lack of benefit may be related to the limitations in biomarkers used.
Thus, induction of ER stress by palmitate turns on multiple pathways aimed to attenuate protein synthesis in β-cells exposed to glucolipotoxicity.
These results underscore the ability of EPO to counter injury effects on multiple pathways.
Enhanced growth was associated with activation of biochemical signaling on multiple pathways.
Similar(37)
In large part, the complexity of treating these disorders results from our insufficient understanding of the contributions of multiple pathways on disease pathophysiology.
This coordinated change, induced by SST on the activity of multiple pathways, implicates a common regulatory mechanism controlling the multiple pathways.
Here we review current knowledge on the multiple pathways controlling tumour angiogenesis and assess which are the most clinically relevant.
Mutant AR protein might exert its toxic effects on neurons through multiple pathways, including disruption of protein folding homeostasis, interference with protein degradation, transcriptional dysregulation and/or by inhibition of axonal transport.
The effectiveness of single pathway inhibition could be suppressed by de novo dependence on multiple signaling pathways or feedback activation of other signaling pathways in response to the inhibition of a single pathway [ 2, 5].
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