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THE BOTTOM LINE -- The effect of height on life span, if any, is unclear.
It has only a modest effect on life span, but it causes costly chronic illnesses, like diabetes.
Researchers have identified some impacts of these interactions on life span.
In contrast, motor-neuron-specific over-expression of MnSOD had no detectable effect on life span.
Moderate level over-expression of MnSOD has beneficial effects on life span.
For more on life span research we've covered in Science, check out our recent stories here, here, and here.
"It had more of an impact on life span than I would have predicted," van Deursen says.
Recently, Simons et al. have shown that mice with heterozygous deficiency of PI4KIIα do not display effects on life span (Simons et al., 2009).
Yes, living on or among mountains could actually have an impact on life span.
Accordingly, mutations of genes in this pathway will have the largest effect on life span.
These results mirror the impact of isoform-specific mutations on life span.
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