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Special regulatory designations allow drugs to be approved at earlier stages based on less rigorous clinical testing; for example, one review showed drugs with orphan designations or granted accelerated approval are also more likely than drugs without these designations to be tested in single arm studies without placebo or active comparators.
In comparison, the DNA barcode approach relies on less rigorous analysis techniques using universally sampled sequences from only one or rarely two markers.
Favorable comparisons are made to predictions based on less rigorous describing function or harmonic balance techniques.
Some observers worry that new endpoints could cause FDA's standards to slip: "Is this going to allow drugs to get on the market based on less rigorous studies?" asks Peter Lurie, deputy director of health research at Public Citizen, a Washington, D.C., advocacy group.
25 The results also add to the strength of a recent Cochrane review based on less rigorous studies, 18 which reached similar conclusions.
For example, whereas psychopharmacological interventions have the broadest evidence base, other areas based on less rigorous studies may be similarly relevant for the long-term course of psychiatric disorders.
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This was to acknowledge that evaluating community-level interventions in randomised controlled trials is difficult and that policy on implementation of these is often made on the basis of less rigorous evaluations.
When I spoke to parents of children with special needs, several wondered if the higher Ofsted grades were a function of less rigorous expectations on special schools.
Perhaps this moral assurance led to less rigorous plotting.
And the Internet reduces the academic price that students pay for going to less rigorous schools.
It is best to gain some experience on much less rigorous campouts before going on a backpacking trip, as there is much less risk involved in the less rigorous campouts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com