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In our method each gene is assigned a score based on its fold change, and we create a pseudo pathway, which is proportionally larger than the original pathway.
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As more results and techniques become available, it helps to learn more about why a particular region of a protein may have a stronger influence on its folding and stability.
As a consequence, the strategy of judging the biological relevance of a single transcript solely based on its fold-change or significant p-value is prone to be hampered by random effects.
As for proteins, RNA function depends on its folding to a well-defined three-dimensional shape.
Each probe has a score on the basis of its fold change relative to the standard deviation of repeated measurements for this probe.
MiR171h has later been predicted to be produced from an 811 bp long primary transcript encoding two miR171h loci on a single arm of its fold-back structure [[ 31]].
To identify which testis- and ovary-upregulated genes demonstrated the highest gonad specificity, we ranked each gene based on its average fold change ranking across each absolute expression analysis dataset.
The 10.5 μM KD interaction between the surface patch on VAMP7 longin domain and a portion of the Hrb unstructured C-terminal domain must be highly specific to these two components, because the topography of the VAMP7 longin domain surface is dependent on its overall fold, and the sequence of the Hrb-binding fragment is not found in other clathrin adaptors.
With a laying on of hands, the Evangelical Lutheran Church in America on Sunday welcomed into its fold seven openly gay pastors who had until recently been barred from the church's ministry.
Carbon 3 projects at right angles to this line, but the acyl chain on its glycerol folds over at the carboxyl carbon to lie alongside the acyl chain on carbon 1. Triglyceride molecules look much like a tuning fork and, when packed together, produce layered crystals.
Based on its motif folding, RNase domain was redefined as the KEN (kinase-extension nuclease) domain.
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