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Depending on its conformation, Hsp90 recruits various co-chaperones to assemble two distinct complexes, one of which favours proteasome-dependent degradation of the client protein and one that favours stabilisation (Meyer et al, 2003).
DS and molecular weight had great influence on its conformation in aqueous solution.
Tsai, H.M. Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion.
Each attached motor exerts, on the actin filament, a force that depends on its conformation and its relative position with respect to the actin monomer to which it is attached.
The cyclic peptide that mimics the immunodominant sequence of gp45 showed excellent reactivity, thus suggesting that its functional activity depends significantly on its conformation, since very low reactivity was observed in the linear form of the peptide.
We previously concluded that, judging from NMR chemical shifts, the effects of insertions into ubiquitin on its conformation appear to depend primarily on the site of insertion rather than the sequence of the insertion.
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Molecular simulation was performed to comment on its stable conformation and optical changes observed due to electronic distribution in the presence of DNA.
The S-nitrosylation of complex I in heart mitochondria depends on its structural conformation and has implications for hypoxic conditions.
The enhancement of enzyme activity due to solvents could be attributed to lipase disaggregation, some structural changes in the enzymes (maintaining the lipase on its open conformation), and even modification at the oil-water interface to facilitate enzymatic action [ 57].
This would be a structurally-destabilizing mutation in a typical RNase A family ribonuclease; however, given unusual amino terminus encoded by the complete open reading frame within the RNase 8 transcript (see below), it is not at all clear what the impact of this polymorphism might be on its final conformation.
Nanosecond emission anisotropy of fluoresence-labeled severin shows that this protein changes its conformation on binding Ca2+.
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