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Yet to date, most work on ISCC design has focused on high-level treatments of system viability and potential impact, without thorough consideration of system operations.
Previous studies on ISCC showed that p53 overexpression is not usually associated with gene mutation but with sequestration by cellular or viral proteins of which mdm-2 is a highly possible candidate.
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p53 gene mutations were detected in 5 (11.6%) cases of ISCC only, 3 of them showed protein overexpression.
All samples positive for cyclin D1 expression were scored except for 6 cases of ISCC that scored.
Therefore they could be used as surrogate markers for early detection of ISCC and for monitoring patients with cervical dysplasia.
However, it is interesting to note that, in this study, all cases of ISCC with a positive cytology were detected by HCII methodology, which is reassuring information altogether.
Similarly, CDK4 expression was significantly increased from CINI to ISCC (p = 0.001).
The positivity index for Ki-67 was significantly increased with progression from NCT (< 0.1) to ISCC (40.5 ± 11) (p = 0.003).
Focus was laid on the three certification schemes - ISCC, Bonsucro and RSB - as they are results of multi-stakeholder initiatives, were accepted to fulfil the EU RED requirements and are mainly discussed to be applied on the production sector in Brazil.
The following section will give an overview on social aspects within the selected certification schemes ISCC, Bonsucro and RSB.
For the ISCC and RSB schemes, the focus is on biofuels in general.
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CEO of Professional Science Editing for Scientists @ prosciediting.com