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Thus, the Nx system appears to promote ON internalization in HeLa cells as efficiently as more classical lipoplex formulations.
Because ADCs generally rely on internalization for cytotoxicity, one sensitive and one nonsensitive AML cell line were evaluated for anti-SAIL mAb internalization.
The commission said it would study trading on Nasdaq and the New York Stock Exchange to see if further steps were needed on internalization and payment for orders.
The effect of surface charge also has a profound effect on internalization capability.
Antibody-drug conjugates are generally believed to crucially rely on internalization into cancer cells for therapeutic activity.
The therapeutic effects of the drug-loaded polymeric nanoparticles were dependent on internalization and sustained retention of nanoparticles by tumor cells.
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Complement, when available, is activated by NMO-IgG remaining on internalization-resistant AQP4 [ 88- 91] expressing astrocytes.
On one hand, internalization of IL2R might shorten the tumor retention of Dmab scFv -Fc antiboDmab scFv -Fc
34, 35 These results are in the same vein as stereotype activation based not on stereotype internalization, but on the stereotype threat paradigm.
The mechanisms of action of BoNTs on neurotransmitter release depend on toxin internalization into neurons and the specific cleavage of synaptic proteins.
Further, peptides isolated by phage display screenings are commonly selected based on receptor binding but not on subsequent internalization, nuclear transfer, and transgene expression.
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