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Its analysis was performed on individual parameters of the etch rate, selectivity, and profile.
Italian journals also scored worse on individual parameters of editorial leadership, even though UK journals have room for improvement.
Data on individual parameters and clinical outcome measures are summarized in Tables 3 and 4 respectively.
46 Despite this understanding, PK/PD modeling of drug effects is often conducted separately on individual parameters.
Using this approach, the effect of a number of covariates on individual parameters may also be analyzed [ 16, 17].
Another difficulty in BMA analysis is the selection of prior specifications on individual parameters and model space [ 57].
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The existing optimization techniques are typically based on individual parameter estimates that treat each parameter as independent.
Therefore, steady-state concentrations of proteins depend on clusters of parameters rather than on individual parameter values.
In order to apply this approach to clinical practice, one would need to evaluate uncertainty of treatment outcome prediction by using the whole a posteriori distribution of individual parameters, i.e., by incorporating uncertainty on individual parameter estimates.
It is important to remember that while the parameters of the Siler model are notable for their meaningful interpretations, inference based on individual parameter values should be undertaken cautiously, due to the high correlation between model parameters (see Hartmann 1987) and the co-determination of best-fitting parameter values by our maximum likelihood estimation procedure.
To evaluate the impact of a priori information on individual parameter estimation and outcome prediction, we modified fixed effects of some parameters to generate two false models (Table 2 ): for M δε, we set δ and ε to the values obtained in GT-1 infected patients; for M β we set β to the upper limit of possible values found in literature.
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