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My experiences represent but one human data point on these issues.
Many therapeutic areas that rely on human data to validate targets as animal models are seen as poorly predictive.
The results on human data indicated that fusion, thickness adaptive and postprocessing options provided the best muscle/fat segmentation scores in both Level Set and Bayesian methods.
To prepare for BCI clinical application in patients, preliminary studies on human data have been carried out using non-invasive magnetoencephalography (MEG).
The PSSMs were calculated as described above, using the original NetMHCpan method trained only on human data.
A similar approach has recently been used on human data to identify three principal components of human sleep that involved 1) sleep duration, 2) NREM intensity and 3) sleep continuity [11].
To this end we focused on human data sets and used data published by Chabardes-Garonne et al [26], Higgins et al. [27], Cuellar et al [28], and Nyström et al. [29].
Only interactions based on human data were included.
Till that we have to rely on Human data.
They, too, applied their method on human data.
Although many OELs are based on animal data, many are based on human data as well.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com