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Budd's description of redundancy is focused on functional overlap (Budd 2006).
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It is noteworthy that ESA1 and GCN5 show a significant level of functional overlap on gene promoters [36].
Based on the reports of functional overlap of SigB and PrfA in regulation of L. monocytogenes gene expression [40], [53] [60] and the fact that SigB is one of the most characterized stress response regulators of L. monocytogenes [52], it seemed logical to investigate whether the stress-associated fitness defects exhibited by the prfA* mutants were related to alterations in SigB function.
However, the small degree of functional overlap is not mediated by cross-reactivity at the level of mpl receptor expressed on the surface of megakaryocytes [ 10].
Annotated pathways were then connected according to functional overlap.
To gain insight into the binding of PDZ domains on this genomic scale and the actual impact of sequence similarity on the functional overlap of PDZ binding, we firstly identified the PDZ domain complement of the human genome and fourteen other genomes.
This report is focused exclusively on redundancy through functional overlap with a paralogous gene.
They also speculated on a possible functional overlap between XIPs and NIPs because of their similarity in the substrate spectrum and in the selectivity pore.
We were looking for functional overlaps among the 968 overlaps longer than 60 bps.
This study explored this hypothesis by evaluating the functional overlap of the signatures on the basis of annotated gene sets.
For further analysis, ROI selection was based on functional activation overlap between CBF and BOLD but was restricted to the morphometrically defined visual cortical areas BAs 17, 18, and 19 (see above).
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