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This chapter focuses on functional imaging of the human brain.
It may also be applicable for studies on functional imaging of the macaque brain, by constructing it of non-magnetic materials.
In the TZ, T2W imaging is now recognised as the most important pulse sequence for detection of PCa because of overlap between TZ cancer and stromal BPH on functional imaging (see Interpretive pitfalls, stromal BPH) [58].
The PET-based SUVs are semi-quantitative measurements based on functional imaging often used with a different purpose in a clinical study: patient inclusion/exclusion, response monitoring, follow-up, and as prognostic and predictive IB.
This review highlights a number of considerations that arise when these techniques are employed in pursuit of this goal, with a particular emphasis on functional imaging studies of retrieval from episodic memory.
The assessment of eligibility for treatment is challenging and relies heavily on functional imaging modalities that provide physiological information, in addition to structural data acquired by different imaging techniques.
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So far, to our knowledge only one study has reported on results of functional imaging following RIT of glioma.
Only one series has looked at the effect of functional imaging on GTV definition in pancreatic cancer.
No published data on the correlation of functional imaging with histopathology have been reported.
Due to the rare nature of laryngeal NETs, there is a paucity of data on the value of functional imaging with conventional scintigraphic agents and no data to guide the use of emerging PET tracers described above.
Although the aim of this review was to assess the predictive and prognostic utility and the additional benefit of functional imaging on target volume definition in oesophageal and pancreatic cancer, the lack of heterogeneity in the functional imaging modalities used and the large degree of variation in technique and reporting make comparison of the results challenging.
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