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This and various other methods that have been devised to identify functional residues in proteins, such as residue interaction graphs (Amitai et al. 2004) or statistical methods reviewed by Ahola et al. (2004) could reasonably be used in conjunction with structure-based alignment methods to determine reasonable alignments based on functional considerations.
However, based on functional considerations it appears unlikely that the reduction of the male leg armature preceded the behavioral change given that the leg armature has been experimentally shown to be important for successful mating in sepsids [ 37, 44, 51, 76].
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In order to understand the nature of functional considerations that may govern the network organization, we focus on the overlap of several previously identified functional circuits of C. elegans with the structurally identified modules.
The arguments presented in the next two sections are based on design and functional considerations.
Based on expressional and functional considerations, additional omentin sequence variations not yet described should be investigated in cohorts of patients with T2D or IBD.
We chose to study the ALAD polymorphism based on a priori biologic and functional considerations and not by screening a large number of associations.
With the example of vertebrate phototransduction cascade we demonstrate that all of the relevant engineering parameters are controlled by enzyme concentrations and, from functional considerations, derive bounds on the required protein numbers.
On the basis of biochemical and functional considerations, the term autophagic cell death is used to indicate a death instance mediated by autophagy, suppressed by the inhibition of autophagy by chemicals and/or genetic means.
But I wondered, is choosing a breadbox just a matter of style, or are there functional considerations, too?
"Their singular approach illustrates the notion that design is not only about industry or formal and functional considerations, but also about ideas".
Decisions relating to size of offices and their furnishings are basically arrived at through functional considerations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com