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To evaluate the effects of the protocol on functional connectivity, we recorded at least one hour of spontaneous activity before and after the protocol.
As a second evaluation step, we investigated the influence of method and condition on functional connectivity and, more specifically, on one global measure (integration), two pairwise measures (marginal and partial correlation), as well as on the global pattern of correlation.
However, prudence is warranted when attributing specific molecular mechanisms to the ATD effect on functional connectivity because we did not measure 5-HT metabolism or receptor function.
Mixed ANOVA were performed to investigate the effect of group (between-subject factor), connection (within-subject factor) and connection type (within-subject factor; frontotemporal, frontoparietal and temporo-parietal) on functional connectivity strength.
Neuronal activity can have profound effects on functional connectivity at the level of synapses.
As the reliability and suitability of these approaches were unclear, building atlases based on functional connectivity was imperative.
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In self-pain, Seminowicz and Davis [ 50] propose that pain and attention processing rely on functional connectivities between aMCC and prefrontal regions.
This, in principle, allows one to study the effect on the functional connectivity caused by lesions to the synaptic connections.
How antagonistic effects on NMDA receptors and agonistic effects on AMPA and kainate receptors translate into models of hippocampal function will depend on the functional connectivity of the zinc-containing deep CA3 and superficial CA1 pyramidal cells.
These findings provide a new perspective and shed light on how functional connectivity and the balance of within/between module connections may contribute to both the state of consciousness and the development of absence epilepsy.
Exploring these types of models promises to shed light on how functional connectivity estimates from different recording techniques relate to one another and on the neural mechanisms that give rise to functional connectivity.
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