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The perchlorate dose (milligrams) assumed for serum collected on exposure day 14 was the assigned daily dose (0.007, 0.02, 0.1, or 0.5 mg/kg), multiplied by a subject's body weight.
In the uptake study, serum perchlorate was not measured, and thyroid function measurements were made only from blood samples collected at the screening visit and on exposure day 14 (0800 hr).
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Samples of blood were collected from each animal 3 or 4 days before exposure began, on the first day of exposure (day 0), and on multiple days thereafter (usually days 1, 2, 3, 5, 7, 9, 12, and 15).
Clinical observations of the animals were recorded for each animal at least three times per day on exposure days and once a day during the pre-exposure and post-exposure periods.
The associations we observed in the analysis of ever use of glyphosate (Table 2) for melanoma, rectum, kidney, and bladder cancers were not confirmed in analyses based on exposure-day metrics; similarly, no exposure response patterns were observed in analyses using never exposed as the referent or in analyses across quintiles of exposure (results not shown).
On the exposure day, D-4F was administered after the mice were returned to housing cages.
On the exposure day, participants were randomized into equal-sized groups of bathers and nonbathers.
Likewise, measurements of O-T intervals were made during the final episode of hypoxia on each exposure day.
The HRV spectra of Figure 5 illustrate activity in the LF region of a RSGX animal and a SHAM animal during a representative hypoxic episode on each exposure day.
On each exposure day the pairs were separated for 1 hr prior to social interaction (SI) (i.e., the observer remained in the home cage and demonstrator was removed).
Within each pair, one subject was randomly assigned to breathe CAPs on the second exposure day and filtered air at other times.
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