Approaches that do give such results tend to be based on network generalizations of existing principles in molecular biology: guilt-by-association, homology and differential analysis.
That letter also said it was "vitally important that the publicly funded healthcare system be preserved and renewed, on the existing principles of universality, accessibility, portability, comprehensiveness and public administration," and went on to call not just for preservation but for an "updated range of services".
Current rapid technological advances in whole genome DNA sequencing, based on novel or previously existing principles, are gradually replacing established Sanger method variants.
The report also restates its 14 existing principles.
But can we improve the existing principles?
The media intervention tested in the trial was designed and implemented based on DMI's Saturation+ approach, which builds on existing communication principles for behavior change.
It is difficult to distinguish internal fault and external fault only based on existing protection principle.
This framework is based on existing models and principles of health system evaluation, explicit theory, consideration of the empirical literature on determinants and indicators of inter-professional collaboration, and previous evaluations of palliative care systems.
We show how active tectonics can produce dynamic landscapes with geomorphological and topographic features that may be critical to long-term patterns of hominin land use, but which are not typically addressed in landscape reconstructions based on existing geological and paleoenvironmental principles.
However, we are far from solving the protein folding problem and arguably progress is based more on existing structures than first principles.
