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Senior walking behavior was measured through on-site observations, and sum of observed seniors on each pathway segment was the dependent variable.
Regression analysis indicates that pathway global integration value (degree of syntactic accessibility) and control value (degree of control on accessing neighboring pathways) are positively associated with number of observed seniors on each pathway segment.
Specific gene nodes on each pathway were 'painted' according to the direction of differential expression of that gene on day 7 of DSS treatment: red if up-regulated, green if down-regulated.
Combining principal component analysis, PCA, on each pathway with correlation of the derived metaproteins to phenotype produced results that are both consistent with literature as well as new findings.
The standardized regression coefficients are presented in the diagram on each pathway.
Next, the median value of statistics over the entire permutation process was computed on each pathway.
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To test this hypothesis, pathways were manually classified into 8 categories based on the description of each pathway in PID.
The number of mapped reads of the transcripts belonging to the same pathway was summed up to determine the expression of each pathway on time (Additional file 9).
Since both the MAPK and PI3K/Akt/mTOR pathways are activated by HER2 and known to regulate HIF-1α expression and activity [ 44, 48, 49], the effect of specific inhibition of each pathway on HIF-1α expression was also studied.
While diverging in their carbon-carbon elongation reaction mechanism, iterative operation of each pathway relies on common chemical conversions (reduction, dehydration, and reduction) differing only in the attached moiety (acyl carrier protein (ACP) in FAB vs Coenzyme A in r-BOX).
Similarly, gene set enrichment analysis (GSEA) evaluates association evidence of pathways by calculating and testing an enrichment score of each pathway based on how its constituent genes are ranked by their statistical significance associated with disease [ 10].
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