Twelve of these patients (60%) reported either no new symptoms or one new symptom on discontinuation, as assessed using the DESS scale scores.
The number of patients experiencing at least one treatment emergent adverse event, the number of patients experiencing at least one adverse event that emerged on discontinuation, and the frequency of each named event needed to be reported.
In one patient, the serum TG level doubled on discontinuation of fenofibrate therapy and had to be restarted.
We assume that 40% of patients will discontinue treatment at 12 months based on Australian data on discontinuation of statins [ 21] and blood pressure-lowering drugs [ 22].
The literature review showed that although there is more than 20 years of research on discontinuation from fertility treatment, many studies did not address why patients discontinued treatment (<60% of papers investigating discontinuation, see Fig. 1).
However, in some studies the endpoints were clearly not comparable, including one [ 42] where the endpoint was any type of oral lesion and one [ 47] where the definition specifically excluded alterations that resolved rapidly on discontinuation of ST use.
Changes in glycaemic control were, on average, small during 12 months after discontinuation of rosiglitazone, although about one-third of the patients had evidence of loss of glycaemic control on discontinuation.
The number of routes in the region will be reduced on discontinuation of two airports.
This period was chosen because clinical data on relapse on discontinuation were taken from trial lasting between 26 and 104 weeks.
The marginal effects on long-term continuation and on discontinuation are also included in this table, although these outcomes will not be discussed in depth.
An early and accurate therapeutic response evaluation is critical in PM as it can influence the decision on discontinuation of treatment, treatment adjustment and/or additional treatment.
