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Alternatively, distinct subunits are engaged on different cell phenotypes by genetic control (genetic determinism) and/or selective recruitment under physiopathological conditions and epigenetic stimuli (epigenetic determinism).
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It is also experimentally easier to understand the impact of stochasticity on the steady-state behavior (by measuring the fraction of different cell phenotypes in an experiment).
Additionally, we have also studied the myofibroblast differentiation potential of different cell phenotypes involved in FBR.
This enables concurrent identification of different cell phenotypes and functional markers in high complexity staining.
These findings suggest that mesothelial cell progenitors are able to switch between different cell phenotypes depending on the local environment.
The analysis of Mmp9 / and mice3–/– mice during bone repair revealed that each of these enzymes acts on different cell types to produce comparable phenotypes.
Dendritic cells (DCs) are a heterogeneous group of bone marrow-derived cells within various organs, which display different cell surface phenotypes and serve different functions depending on location, development, and activation status.
Moreover, many tissues depend on several different cell types with given phenotypes.
This study suggests that contextual activation of the ERK pathway results in different effects on cell phenotype, depending on the geometry and composition of the ECM.
These analyses are mainly based on functional association of changes in gene expression between different cell states or phenotypes.
Fig. 6 Effects of Ca2+/hypoxia on the stem cell phenotypes of hUCB-MSCs.
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