Chronic usage breaks the associative relationship between taking a medication and having sex 1 h later, which is one of the most frustrating disadvantages of the on-demand regimen.
Table 4 compares the ICERs between the three ITI protocols and the on-demand regimen.
Comparison of the incremental cost-effectiveness ratios between the three ITI protocols and the on-demand regimen with rFVIIa shows that all three ITI protocols dominate the on-demand regimen with rFVIIa.
Comparison of the ICERs (Table 4) between the three ITI protocols and the on-demand regimen with rFVIIa shows that all three ITI protocols dominate the on-demand regimen with rFVIIa.
This was a Phase 3, randomized, multicentre, open-label, two-arm parallel study comparing prophylaxis to an on-demand regimen.
The on-demand regimen versus scheduled use was evaluated in 4262 patients in a cross-over open-label study conducted to assess patient's choice of treatment regimens.
A secondary analysis (negative binomial mixed effects model) further confirmed an increased incidence of bleeding was associated with the on-demand regimen.
Forty seven percent of the attempts on the on-demand regimen and 71% on the 3 times/week treatment were performed by patients more than 4h post-dosing.
On these bases, RTX infusions (1,000 mg twice with an interval of 2 weeks) every 24 weeks in combination with long-term steroids might be a better strategy when compared with an on-demand regimen.
The prophylactic regimen of FEIBA NF in haemophilia A and B subjects with inhibitors yielded a statistically significant and clinically relevant reduction in the number of all bleeding episodes when compared in a prospective manner to the on-demand regimen.
