Alternatives to reduce costs associated with biologics have been examined, including on-demand dosing and lower dose alternatives.
15 These pharmacokinetic characteristics make dapoxetine ideal for on-demand dosing, which reduces the probability of unwanted side effects.
The unique pharmacology of dapoxetine makes it ideal for on-demand dosing, allowing great convenience and flexibility for the patient.
On-demand dosing as well as dosing for the treatment of bleeding while on prophylaxis was dependent upon the type of bleeding and was at the discretion of the investigator (as described in the Supporting Information).
The unique pharmacology of dapoxetine makes it ideal for on-demand dosing, and the clinical evidence shows dapoxetine to be an efficacious and tolerable treatment for lifelong and acquired PE.
We suggest consider prescribing at least half of total daily dose "by the clock" (opinion MSP) e.g., Acetaminophen 500 mg four times a day and remaining dose could be given "on demand" or in combination with other agents.
Analgesics should not be taken "on demand" but "by the clock" (every 3 6 hours), with each dose delivered before the preceding dose has worn off, in doses sufficiently high to ensure continuous pain relief.
The V-Go® Disposable Insulin Delivery Device (Valeritas, Inc., Bridgewater, NJ, USA) allows for continuous subcutaneous delivery of a basal rate of insulin over a 24-hour period with on-demand bolus dosing at mealtimes, eliminating the need for multiple injections throughout the day.
A drug-loaded hydrogel composed of reduced GO and poly vinyl alcohol) enabled on-demand control of dosing via modulation of drug-release rate with the application of an external electric field.
This is a prospective observational study, controlled with on-demand assignment of alprazolam doses in variable doses.
Median (minimum maximum) weight-adjusted dose per infusion was 81 U kg−1 (72 91) in the prophylaxis arm and 70 U kg−1 (50–106) in the on-demand arm, and the dose for treating breakthrough bleeding during prophylaxis was 82 U kg−1 (48 97).
