Sentence examples for on constant region from inspiring English sources

The forward primers for the VL and VH were based on constant region sequences.

CARs frequently incorporate a spacer/linker region based on the constant region of either IgG1 or IgG4 to connect extracellular ligand-binding with intracellular signaling domains.

Allotypes expressed on the constant region of IgG heavy chain are designated as Gm (Genetic markers) together with the subclass.

The isotype of each sequence is determined based on the identified constant region primer and then 100,000 sequences is randomly selected to be aligned to VH germline genes using IMGT/HighV-Quest.

General TLM yields the straight line with slope of 45° in the distributed constant region on the Nyquist plots.

The efficacy of a therapeutic IgG molecule may be as dependent on the optimisation of the constant region to suit its intended indication as on the selection of its variable regions.

A schematic representation of the cloning strategy is shown in Fig. 1 A. The murine variable regions of mAb 62-71-3 were grafted on the constant regions of a human mAb (IgG1 κ), using the primers listed in Table 2 and the cloning strategy described in Supplemental Data.

Mice bearing a defective γ3 heavy chain constant region gene on a mixed 129 and C57BL6/J [ 30] or a BALB/c background [ 27] have been described.

Several independent studies have clearly shown that effector functions of recombinant therapeutic IgG are directly dependent on the glycosylation of the constant region (Fc) [ 1- 3].

The other clusters were based on annotations of immunoglobulin heavy constant region (score of 5.57), immunoglobulin variable region (score of 3.55), structural constituent of cytoskeleton (score of 3.55), and cell adhesion (score of 2.94).

The partially rearranged V region on chromosome 8 and the mu constant region downstream of re-VH are not diversified by hypermutation.