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Thus, it was assumed that a GPCR can exist either in an "off" or "on" conformation causing either no activation or equal activation of all its signalling pathways.
We revealed that while the majority of the apo SMK box RNA molecules exist in an alternatively base-paired (ON) conformation, a subset of them pre-organize into a SAM-bound-like (READY) conformation, which, upon SAM exposure, is selectively stabilized into the SAM-bound (OFF) conformation through an induced-fit mechanism.
This experiment tests the effect of 60° binning on conformation sampling.
An impact of fluorine atoms on conformation, lipophilicity, acidity and fluorescent properties of the amino acid has been studied.
Novel tricyclic derivatives 2a e were designed as CRF1 receptor antagonists based on conformation analysis of our original 2-anilinobenzimidazole Creceptorptor antagonist.
The chapter gives details of crystal structures of collagen peptides and the effects on conformation of the precise sequence of the distinct constituent triplets.
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The limited mean molecular area obtained by π A isotherms revealed an "edge-on" conformation for all these compounds.
Examination by spectroscopic methods revealed APDI molecules in the hybrid film adopt a typical H aggregation mode whereas those in pure film adopt a slipped co-facial stacking mode in an "edge-on" conformation.
In the hierarchical ordered structure, P3HT domains are vertically arranged and the domains are constituted by uniaxially aligned P3HT nanofibrils, furthermore, the chains in it adopted flat-on conformation.
The vertically arranged domains are formed by the action of capillarity, the oriented nanofibrils are induced by the crystallization nucleation of P3HT and the directional evaporation of the solvent, and the flat-on conformation of P3HT chains are induced by the enhanced intermolecular interaction of the alkyl side chains in CS2 atmosphere.
Functionalization is mainly carried out at the edges of the GO sheets, so the GO-sheets are not totally covered, even by increasing the PPE-vs-GO ratio because of the trend of the PPEs in to self-assemble in an "edge-on" conformation, meaning that the conjugated backbones are parallel to the GO surface, rather than in "face-on", where the backbones are flat-lying on the GO surface.
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