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Digital PCR has the advantages of economy, speed, and not relying on an informatics infrastructure.
In future editions of GigaScience, we will be working with authors to make the computational tools and data processing pipelines described in their papers available and, where possible, executable on an informatics platform.
Based on an informatics method (SCUO) we developed previously using Shannon informational theory and maximum entropy theory, we investigated the quantitative relationship between codon usage bias and GC composition.
The NMVB database is based on an informatics model that aids in achieving semantic and syntectic interoperability by describing the common data elements in the form of metadata or data descriptors and by using a controlled vocabulary in order to make the data understandable and sharable for end-users.
The MVB database is based on an informatics model that aids in developing and conveying the semantic interoperability by describing the common data elements in the form of metadata or data descriptors (about the content, quality, condition, and other characteristics of the data) and by using a controlled vocabulary and ontology in order to make the data understandable and sharable for end-users.
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Several long term projects seem to be working on such an informatic platform but face numerous difficulties in the integration of biochemical data, in the development of graph traversal and optimization algorithms, and in the creation of flexible interfaces for researchers to use.
Edward Jones directs an informatics project on human and monkey brain atlases (Jones Laboratory University of California Davis 2007) (Fig. 5).
We are now developing an informatics resource based on the BBRAF clones that will function as a bridge between information for the model plant Arabidopsis and Brassica research.
In this paper, we applied an informatics method [ 13], which is based on Shannon informatics theory and the entropy theory, to explore the relationship between GC composition and synonymous codon usage bias among 70 bacterial and 16 archaeal genomes.
Such information can be combined with genomics and other molecular profiles on a common informatics platform to provide a rich matrix for data mining and hypothesis testing.
These analyses were performed as part of the validation of WES/WGS as a clinical test in our laboratory and as a result focus on a single informatics pipeline and exome capture technology.
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