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Finally, CML and non-small cell lung cancers with activating EGF receptor mutations may be exceptional examples due to their dependence on a single driver mutation that can be targeted directly by tyrosine kinase inhibitors.
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We conduct an extensive computational study to quantify the impact of different types of participants' flexibility on the performance of a single-driver, single-rider ride-sharing system.
Since the spring of 1986, not a single driver on the bridge has had to pay a toll to reach Brooklyn.
Such indicators, Mr. Starr told the contractors, include cars that have a single driver but ride unusually low on their suspensions due to the weight of explosives.
Toyota is working on developing flying cars, with the aim of having a single driver vehicle ready to fly in time for the 2020 Olympic Games in Tokyo.
However, restoration measures are nowadays mainly a reactive, site-by-site activity, driven by a single driver (e.g. fisheries, flood protection) rather than based on strategic planning.
A single driver costs hundreds of pounds a day.
The world's largest taxi firm does not own a single vehicle, or employ a single driver.
Not a single driver from the fit group was evaluated as a poor driver whereas fourteen of the 148 "unfit" drivers (9.5%) were.
Two objectives have been achieved: the design and the implementation of the database and the software tools for data access depending on a single software driver.
A current mutation screening program for tailored targeted therapies is also on-going in 1,000 patients with advanced lung adenocarcinoma based on 10 single driver mutations: KRAS (25%), EGFR (23%), ALK rearrangements (6%), BRAF (3%), PIK3CA (3%), MET amplifications (2%), ERBB2 (1%), MEK1 (0.4%), NRAS (0.2%), and AKT1 (<0.1%) [ 30].
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