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(a) Inhibitor acting on a signalling pathway upstream and downstream of a 'merger' node (black circle).
It was recently reported that tissue growth in Drosophila also depends on a signalling pathway involving the lammelipodin homologue Pico and the Mal/SRF transcription factor [4].
On a signalling level, we identify strong correlations of RKIP-loss in the tumour centre with nuclear translocation of NF- κB and loss of E-cadherin expression.
Moving forward the ability to combine observations on various interventions from separate experiments on a signalling, metabolic or regulatory pathway might be used to examine their interactions and maybe generate hypotheses on the impact of combinations of mutants.
Efficient execution of these steps, however, was suggested to depend on a signalling cascade that is triggered upon engagement of the chemokine receptor and entry co-receptor CXCR4 by the viral glycoprotein Env.
This is one of the first examples of a single O-GlcNAc site on a signalling protein modulating a key innate immunity signalling pathway.
Similar(52)
At the corner of Fifty-fourth, we stopped on a signal from the traffic cop.
What is really going on is a signaling game.
Make each person wear an old hat and then on a signal every one must change hats.
They can only react on a signal and they don't have one [right now].
There is a history of New York mayors setting their sights on a signal goal -- and reaching it.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com