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The current U.S. EPA Environmental Protection Agencyy) reference dose for BPA is 50 μg/kg/d, based on a Lowest Observed Adverse Effect Level (LOAEL) (reduced body weight in a National Toxicology Program chronic rat oral study published in 1982) and a safety factor of 1000 (http://www.epa.gov/iris/subst/0356.htm).
The U.S. Environmental Protection Agency EPAA) has calculated an oral reference dose for BPA of 50 μg BPA/kg body weight (BW /day based on a lowest observed adverse effect level of 50 mg/kg BW/day (U.S. EPA 1993; Welshons et al. 2003).
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