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Based on that given cross-sectional parameters as well as based on a given alignment, a 3D model can be parametrically derived.
Because of the large number of parameter-rich tests of sequence evolution that can conceivably be performed on a given alignment, it is important to clearly articulate the tested hypotheses and use a hierarchical approach to data analysis that allows suitable likelihood tests.
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Thus, for a given alignment, the corresponding shortened alignment of length 10 is contained in the shortened alignment of length 25, which is contained in the shortened alignment of length 50, and so on.
In this context, it can further be stated that "saturation" is not an inherent character of an aligned sequence position in a given alignment, it rather depends on the considered phylogenetic level.
The most commonly-used approach is bidirectional best hits (BRH) of BLAST alignment, with imposition of strict criteria on discriminating E-value over a given alignment length, but various more sophisticated approaches have also been developed [ 22].
It relies on the subroutines Align, which returns the best alignment between two series based on a given set of genes, and ScoreGene, which returns the score of two series when aligned using a given alignment and a specified gene.
K is the number of sites in a given alignment.
α AB means that the site-specific rate factors were estimated by our empirical equation based on the given alignment (for details see Methods).
Based on a given multiple alignment, SDPpred computes Z-score for each alignment column.
MITIE can build a segment graph based on given alignments of RNA-Seq reads to a genome or start with segment graphs obtained by other means, in particular by de novo assembly.
In contrast to classical techniques such as the Hough transforms, which are designed for detecting a specific type of alignment on a given type of input, our approach is independent of the geometric properties of the alignments to be detected, as well as independent of the type of input data.
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