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T lymphocyte development in the thymus depends on a functional microenvironment.
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C-C chemokine receptor type 7 (CCR7) and its ligands direct the migration of mature DCs and establish a functional microenvironment to prime naive T cells.
Mesenchymal cells are also required for the initial development and subsequent maintenance of a functional thymic microenvironment [5], [6].
Förster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
They form elaborate and functional networks with other neurons and also rely on a sophisticated microenvironment that is created by the interactions with other neural and non-neural cell types, which provide structural, metabolic and functional support as well as effective communication (Abbott et al, 2006).
This relies on the fact that the replication of its specificity represents a key factor for the development of a scaffold that could provide a suitable microenvironment for a functional physioanatomic district to substitute the failing one.
A different view of the tumour as a functional tissue interconnected with the microenvironment has recently been described [ 1].
Whether or not loss of S100A10 in the tumour microenvironment exerts a functional role in follicular thyroid neoplasia is a subject of future investigations.
In addition, it has been demonstrated that T-cell subpopulations show a functional plasticity determined by the local microenvironment.
Kinugasa Y, Matsui T, Takakura N. CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the stemness and drug resistance of malignant cancer cells in the tumor microenvironment.
Nucera C, Lawler J, Parangi S. BRAF V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression.
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