The second study was a single-center, prospective RCT designed to evaluate the effectiveness and safety of a discontinuation policy on the duration of antibiotic therapy of VAP (N = 290) [16].
The second study was a single-center, prospective RCT designed to evaluate the effectiveness and safety of a discontinuation policy on the duration of antibiotic therapy of VAP (N = 290) [ 16].
The specialized, Silverlight-based cloud syncing service, KIN Studio, was allowed to run for 7 months after the Kin was discontinued on June 30th, 2010 (a discontinuation which came just 48 days after the device's initial launch).
Constipation occurred in just 9% and rapidly resolved on dose reduction, giving a discontinuation rate due to constipation of just 2%.
Rather than an abrupt "on-off" discontinuation of mechanical ventilation, with or without extubation, many teams prefer a progressive withdrawal of mechanical ventilation (termed "terminal weaning"), because they feel the physical symptoms of airway obstruction may harm the patient and be distressing to relatives and caregivers [28].
Rather than an abrupt "on-off" discontinuation of mechanical ventilation, with or without extubation, many teams prefer a progressive withdrawal of mechanical ventilation (termed "terminal weaning"), because they feel the physical symptoms of airway obstruction may harm the patient and be distressing to relatives and caregivers [ 28].
This period was chosen because clinical data on relapse on discontinuation were taken from trial lasting between 26 and 104 weeks.
We assume that 40% of patients will discontinue treatment at 12 months based on Australian data on discontinuation of statins [ 21] and blood pressure-lowering drugs [ 22].
Similar findings of health related concerns in Kenya are reported in a study on discontinuation of injectables [ 14].
Twelve of these patients (60%) reported either no new symptoms or one new symptom on discontinuation, as assessed using the DESS scale scores.
